AEGIS · Project 13
CD-NDI · AEGIS-P13-CDNDI-001
human-in-command

Λ — Chronic-Disease Health-State Index

One dimensionless number, no-disease → deterioration → death · grounded in Ghista's NDPI & Loh's DBI/VTI

A physician in command before a luminous data wall where seven organ-system signals converge into a single dimensionless health index tracing a green-to-red trajectory

1 · Enter the panel

Patient

Choose a patient from the list to load their record (results & trend from their visit history), or move the sliders below for a manual what-if.

HbA1c (%) — metabolic

eGFR (mL/min) — renal

FEV1 (% pred) — pulmonary

Troponin (ng/L) — cardiac

ALT (U/L) — hepatic

CRP (mg/L) — inflammation

Hemoglobin (g/dL)

Age (years)

BMI

Smokerno

Prior Λ (optional)

2 · Health-state read-out

0.0 Λ

Healthy

0 Healthy12.558 Terminal

—

–%

Health Score (100 = healthy) ·

Λ · Ω

Organ contribution to Λ

The number flags; a clinician decides. Λ integrates the panel into one health-state number and points to the pathway — it does not diagnose. Every call stays with the medical team.

How Λ is derived. Each organ marker becomes a dimensionless deviation z = (value−normal)/(critical−normal) against standard clinical reference ranges (z=0 healthy, z=1 at the critical threshold). Λ = √(Σ wᵢ·zᵢ²), a weighted physiological load; weights (cardiac 1.3, renal 1.2, metabolic/pulmonary 1.0, hepatic 0.9, inflammation 0.8, haematologic 0.7). Bands: Healthy<0.5 · At-risk<1 · Established<2.5 · Progressive<5 · Critical<8 · Terminal≥8. DBI, VTI, RCI shown are the named indices from D.N. Ghista (Nondimensional Physiological Indices, 2009) How Ω & the Health Score work. Λ is where the patient is now; Ω = Λ·T·R projects where they are heading — T a trajectory multiplier (improving <1, declining >1) from the projected 2-year Λ, R a risk multiplier from the distilled SVM deterioration probability. Ω sorts into four action bands shown as the traffic light: Well (<0.6) · Managed (<2.5) · Deteriorating (<7) · Beyond reach (≥7). The Health Score H = 100·(1−Ω/11), clipped 0–100, restates it as one intuitive number (100 = healthy, 0 = beyond help). Illustrative, synthetic research scaffold — not a clinical device; not for patient care.

Population & cost — chronic-disease resource planning

🌍 GLOBAL COVERAGE — planning anchored to the real health-system spend of 24 countries (WHO / World Bank, SGD). Λ is the unifier: one number spanning the whole cardio-renal-metabolic-pulmonary population, not one organ — the grand total of the diagnostic series. Pick your market; the Ω-band cost, focus list and avoidable spend re-compute in your economy.

Chronic-disease / at-risk patients in your service

Market (per-capita cost anchor)

Annual chronic-disease care cost—

Patients needing attention (Deteriorating + Beyond reach)—

Cost avoidable via early multi-organ intervention—

Focus list — Deteriorating, still salvageable—

Case-managers for the focus list (@200 each)—

Referrals routed → specialist consoles—

Ties the individual Λ read-out to the system view: every Deteriorating patient becomes a specialist referral and a case-management load, routed into DRAS / RRAS / cardiac / PRAS. The salvageable band is where the avoidable cost lives — catching multi-organ decline early, before it becomes irreversible.

How the numbers are derived — data vintage & method

Per-capita anchors. 24-country health-system per-capita spend (WHO / World Bank, compiled mid-2026, converted to SGD), shared with DRAS / RRAS / PRAS for consistency.
Cost model. Annual cost = patients × Ω-band cost multiplier × per-capita anchor, using the CD-NDI cohort band mix (Well 2.8% ×0.3 · Managed 56.6% ×1.0 · Deteriorating 26.8% ×2.5 · Beyond reach 13.8% ×5.0 — average ≈1.93× per-capita). Avoidable = Deteriorating patients × per-capita × 40% (early multi-organ intervention effect on the salvageable band). Referral split follows the focus-list lead-system mix (DRAS 47.6% · RRAS 28.1% · cardiac 14.4% · PRAS 9.3%).
Illustrative planning scaffold — not billed figures. Band mix from the 5,000-patient SYNTHETIC CD-NDI cohort; every figure re-computes with your market and population. A clinician makes every call.

A clinician commanding a four-colour traffic-light triage wall, making the final call

The index ranks every life by urgency. The clinician commands every call.Λ/Ω surfaces who is deteriorating and who can still be saved — then hands the judgement to a human. Augmenting the clinician, never replacing them.