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Biomedical Engineering Radiology Brain MRI Tumour Classification

AEGIS TumorSentinel — Brain Tumour MRI Classification System (P24)

P24 classifies brain MRI scans across four tumour categories using a 15-engine AEGIS AI ensemble, routing every case to one of four governance zones based on classification confidence.

0.9997 Binary AUC
99.03% 4-Class Accuracy
15 Ensemble Engines
7,200+ MRI Images
🧠 Open the TumorSentinel Demo Console →

Who this is for

Neurologists & Radiologists

A confidence-zoned decision-support reference for brain MRI review. Four-zone routing surfaces cases requiring specialist deferral before any clinical action is taken.

Researchers

Validated ensemble metrics on a distilled MRI research dataset. Honest per-class accuracy reported as-is. 15-engine AEGIS ensemble with binary and 4-class outputs.

Educators

A live classroom tool: 16 annotated MRI cases across all four tumour classes and all four confidence zones — demonstrating AI-augmented radiology for BME students and clinical AI courses.

Students

See how MRI features translate to AI classification. Explore how a multi-engine ensemble distributes probability across Glioma, Meningioma, Pituitary, and No Tumour categories.

Hospital Planners

A demonstration of AI-augmented brain tumour triage. Zero PHI storage. Zone protocol ensures borderline cases receive mandatory human review before any workflow action.

Clinical AI Developers

A reference implementation of 4-zone confidence routing applied to MRI classification — a design pattern for responsible AI deployment in high-stakes medical imaging contexts.

Three integrated capabilities

P24 combines confidence-zone governance with a four-class MRI tumour classifier and a binary tumour-detection screen, all running through the 15-engine AEGIS AI ensemble on every case.

Capability 1

🚦 4-Zone Confidence Triage

Every MRI case is routed to one of four governance zones based on the ensemble's classification confidence. Zone assignment drives the clinical recommendation — from VERIFIED (act) through LOW (mandatory specialist deferral).

4 zones Confidence-driven routing Specialist deferral
Capability 2

🧬 4-Class MRI Classification

The AEGIS AI ensemble classifies across all four brain tumour categories — Glioma, Meningioma, Pituitary Tumour, and No Tumour — with 99.03% validated accuracy on the distilled research dataset.

4 classes 99.03% accuracy AEGIS ensemble
Capability 3

⚡ Binary Tumour Detection

An independent binary screen separates Tumour from No Tumour across all 7,200+ training MRI images, validated at AUC 0.9997 — the highest-confidence output in the system for preliminary screening.

AUC 0.9997 Binary Tumour / No Tumour Independent screen

Try it now — AEGIS TumorSentinel Demo Console

16 pre-loaded MRI cases spanning all four tumour classes and all four governance zones. Each case shows the full ensemble output: class, confidence percentage, binary screen result, zone assignment, and the clinical recommendation the zone drives.

16 pre-loaded demo cases — 4 tumour classes × 4 confidence zones. Click any case to see the full AEGIS AI ensemble result instantly. Upload your own MRI in Live Mode to generate a shareable retrieval code.

Glioma VERIFIED
Glioma
VERIFIED
Glioma HIGH
Glioma
HIGH
Glioma MID
Glioma
MID
Glioma LOW
Glioma
LOW
Meningioma VERIFIED
Meningioma
VERIFIED
Meningioma HIGH
Meningioma
HIGH
Meningioma MID
Meningioma
MID
Meningioma LOW
Meningioma
LOW
Pituitary VERIFIED
Pituitary
VERIFIED
Pituitary HIGH
Pituitary
HIGH
Pituitary MID
Pituitary
MID
Pituitary LOW
Pituitary
LOW
No Tumour VERIFIED
No Tumour
VERIFIED
No Tumour HIGH
No Tumour
HIGH
No Tumour MID
No Tumour
MID
No Tumour LOW
No Tumour
LOW
🧠 Open the TumorSentinel Demo Console →

All demo cases use synthetic pre-set values drawn from the research dataset. No real patient data. Zero PHI storage.

The four governance zones

Zone assignment is computed from the AEGIS ensemble's classification confidence. The four zones map ensemble confidence to a specific clinical recommendation — protecting patients by ensuring low-confidence cases are never acted on without specialist review.

VERIFIED

High Confidence

Ensemble strongly supports the primary classification. Result can be used to inform the clinical workflow. Clinician confirms before action.

HIGH

Good Confidence

Ensemble reasonably supports the classification but with lower certainty. Radiologist notification recommended before acting on the result.

MID

Elevated Uncertainty

Ensemble uncertainty is elevated. Human review required before any clinical decision. Do not use the classification as a primary determinant.

LOW

Defer — Specialist Required

Ensemble confidence is insufficient for any clinical use. Mandatory immediate specialist referral. The result must not drive any clinical decision.

The four brain tumour classes

AEGIS P24 classifies across all four categories from the brain tumour MRI research dataset, spanning malignant primary tumours, benign tumours, and normal (no tumour) scans.

⚠️ Malignant

Glioma

Primary brain tumour arising from glial cells. Includes GBM (Grade IV), the most aggressive form. Irregular enhancement pattern on MRI. Any Glioma result requires immediate neurosurgical review.

⚠️ Potentially Malignant

Meningioma

Arises from the meninges surrounding the brain and spinal cord. Usually slow-growing; majority benign (WHO Grade I) but higher grades exist. Often presents with dural tail sign on MRI.

✅ Benign

Pituitary Tumour

Adenoma of the pituitary gland. Typically benign with characteristic sellar/suprasellar location on MRI. Endocrine consequences may require management independent of malignancy classification.

✅ Normal

No Tumour

No tumour mass identified in the MRI scan. Validated against 7,200+ MRI images including normal scans. Binary AUC 0.9997 for Tumour vs No Tumour detection.

The biomedical engineering science

P24 is grounded in neuroimaging science, deep learning transfer, and clinical AI safety design. The system uses a 15-engine AEGIS AI ensemble trained on distilled datasets derived from publicly available brain MRI research data.

🧠 Brain MRI and tumour classification

Brain MRI distinguishes tumour subtypes through signal intensity, contrast enhancement patterns, mass effect, and anatomical location. T1 post-contrast, T2, and FLAIR sequences carry distinct diagnostic weight. The AEGIS P24 training corpus spans axial MRI slices across all four categories.

⚙️ AEGIS AI ensemble pipeline

P24 runs a 15-engine AEGIS AI ensemble drawing on deep learning feature extraction and ensemble inference across multiple algorithmic approaches. Engine identity, weights, and architecture are IP-protected under the AEGIS research framework. The output is a class probability distribution and confidence score.

📐 Adaptive governance zone routing

Confidence scores are routed through a zone classifier that assigns each result to VERIFIED, HIGH, MID, or LOW — with each zone carrying a specific clinical recommendation. Zone thresholds are class constants defined in the research framework.

🔒 Zero PHI storage

The web application performs all inference client-side. No MRI image or patient identifier is transmitted or stored. Retrieval codes are self-decoding tokens containing only the classification result — no imaging data.

Validated results — honest accuracy, reported as-is

All engines trained and evaluated on distilled datasets drawn from the brain tumour MRI research corpus under strict train/test separation. Results reported as measured.

0.9997 Binary AUC · Tumour vs No Tumour
99.03% 4-Class Accuracy · AEGIS ensemble
15 Ensemble engines · AEGIS AI
Task System Metric Value Note
Binary detection AEGIS AI ensemble (15 engines) AUC 0.9997 Tumour vs No Tumour · distilled research dataset
4-class classification AEGIS AI ensemble (15 engines) Accuracy 99.03% Glioma / Meningioma / Pituitary / No Tumour
Training corpus MRI images 7,200+ Brain tumour MRI research dataset
Honest note: P24 results are validated on a distilled research dataset. Real-world clinical deployment would require prospective validation on independent institutional data, regulatory review, and full clinical trial. These results demonstrate the system's capability as a research and educational tool — not as a certified medical device.

Dataset integrity and data governance

P24 is trained and validated on a distilled research dataset derived from the brain tumour MRI public research corpus — a widely used benchmark in neuro-oncology AI research.

Not a medical device

AEGIS TumorSentinel is a research and educational demonstration. Nothing it outputs is medical advice. Results must not substitute for clinical assessment by a qualified neurologist or radiologist.

De-identified data only

No real patient data was used in training or demo. All demo cases are pre-set synthetic values. No MRI is stored on any server. The system processes images locally in the browser.

PDPA compliance

Zero PHI storage architecture. Retrieval codes contain only classification meta — no imaging data. Institutional use requires a Data Use Agreement before any data exchange.

Institutional partners receive

Full technical report with validation methodology · AEGIS Desktop Application licence · Progressive clinical trial protocol · DUA provided before any data exchange.

All enquiries to [email protected]. International partnerships welcome. DUA provided before any data exchange.

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